Molecular characterization of the hepatitis B virus in autochthonous and endogenous populations in the Western Brazilian Amazon

Revista da Sociedade Brasileira de Medicina Tropical

Ádila Liliane Barros Dias²  Cintia Mara Da Costa Oliveira¹  Márcia Da Costa Castilho²  Maria Do Socorro Pontes Da Silva¹  Wornei Silva Miranda Braga¹ 

[1] ,Universidade do Estado do AmazonasManaus AM

关键词: Hepatitis B virus;    Genotypes;    Epidemiology;    Amazon;    Brazil;    Vírus da hepatite B;    Genótipos;    Epidemiologia;    Amazônia;    Brasil;   

DOI  :  10.1590/S0037-86822012000100003

来源: SciELO

【 摘 要 】

INTRODUCTION: Hepatitis B virus (HBV) infection is a serious public health issue worldwide. Hepatitis B virus is classified into eight genotypes, varying from A to H, with distinct geographical distributions. In Brazil, the most frequent genotypes are A, D, and F. METHODS: This study aimed to characterize the HBV genotypes in cases of hepatitis B virus and hepatitis D virus (HDV) co-infections in an endemic area in the Western Brazilian Amazon. We analyzed 86 serum samples reactive for HBsAg from indigenous and non-indigenous populations obtained from previous serological surveys. RESULTS: Of the 86 reactive serum samples, 39 were found to be HBV-DNA-positive by semi-nested PCR. The genotypes were established by sequencing the amplified S gene region. We obtained 20 sequences classified into three genotypes: A, D, and F. Genotype A was the most frequent (60%), followed by D (35%) and F (5%). CONCLUSIONS: The distribution of the HBV genotypes reflected the pattern of historical occupation of the region.

【 授权许可】

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