Molecular characterization of the hepatitis B virus in autochthonous and endogenous populations in the Western Brazilian Amazon

Revista da Sociedade Brasileira de Medicina Tropical

Silva, Maria do Socorro Pontes da¹  Braga, Wornei Silva Miranda¹  Dias, Ádila Liliane Barros¹  Fundação de Medicina Tropical Doutor Heitor Vieira Dourado, Manaus¹  Universidade do Estado do Amazonas, Manaus¹  Oliveira, Cintia Mara da Costa¹  Prefeitura Municipal de Lábrea, Lábrea¹  Castilho, Márcia da Costa¹ 

关键词: Hepatitis B virus;    Genotypes;    Epidemiology;    Amazon;    Brazil;   

DOI  :  10.1590/S0037-86822012000100003

学科分类：农业科学（综合）

来源: Sociedade Brasileira de Medicina Tropical

【 摘 要 】

INTRODUCTION: Hepatitis B virus (HBV) infection is a serious public health issue worldwide. Hepatitis B virus is classified into eight genotypes, varying from A to H, with distinct geographical distributions. In Brazil, the most frequent genotypes are A, D, and F.METHODS: This study aimed to characterize the HBV genotypes in cases of hepatitis B virus and hepatitis D virus (HDV) co-infections in an endemic area in the Western Brazilian Amazon. We analyzed 86 serum samples reactive for HBsAg from indigenous and non-indigenous populations obtained from previous serological surveys.RESULTS: Of the 86 reactive serum samples, 39 were found to be HBV-DNA-positive by semi-nested PCR. The genotypes were established by sequencing the amplified S gene region. We obtained 20 sequences classified into three genotypes: A, D, and F. Genotype A was the most frequent (60%), followed by D (35%) and F (5%).CONCLUSIONS: The distribution of the HBV genotypes reflected the pattern of historical occupation of the region.

【 授权许可】

Unknown