Active immunization against hepatitis B virus (HBV) with low-doses of plasma-derived vaccine by intradermal route

Revista do Instituto de Medicina Tropical de São Paulo

Flair José Carrilho²  Maria Lúcia Queiroz¹  Luiz Caetano Da Silva²  Luís Edmundo Pinto Da Fonseca²  Celso Granato¹  Isabel Oba¹  Leda Obara¹ 

[1] ,Universidade de São Paulo Faculdade de Medicina Department of GastroenterologySão Paulo SP ,Brazil

关键词: Hepatitis B;    Hepatitis B virus;    Hepatitis B vaccine;    Immunization;   

DOI  :  10.1590/S0036-46651989000200005

来源: SciELO

【 摘 要 】

Schedule for vaccination against HBV infection has usually been based on three separate injections of 20 meg of the vaccine by intramuscular route. One of the main shortcomings to its use in large scale programs has been its high cost. Ninety out of 300 health workers were submitted to three injections of 2 meg of plasma-derived vaccine (PDV) by intradermal (ID) route on days 0, 30, and 180. Anti-HBs was detected in 74 (82.2%) after the second dose and in 80 (88.9%) after the third dose, a non-significant difference. However, levels above 10 times the cut-off were observed in 29 (32.2%) and 77 (85.5%), respectively (p < 0.001). The results showed that a low-dose schedule is effective when used in health workers and should be tried with other risk groups.

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