Otimização do emprego de recursos econômicos para vacinação contra hepatite B em profissionais da área de saúde

Revista da Sociedade Brasileira de Medicina Tropical

Castelo Filho, Adauto¹  Kemp, Vitorio Luis¹  Silva, Antonio Eduardo Benedito¹  Figueiredo, Virgínia Maria¹  Oliveira, Patrícia Marinho de¹  Ferraz, Maria Lucia Gomes¹ 

关键词: works: Hepatitis B;    Immunization;    Hepatitis B vaccine;    Health care workers;    Health economics;   

DOI  :  10.1590/S0037-86821995000400014

学科分类：农业科学（综合）

来源: Sociedade Brasileira de Medicina Tropical

【 摘 要 】

In order to optimize the employment of financial resources to be allocated for hepatitis B vaccination programs involving health care workers', two different aspects were studied: the need of a prevaccination screening and the efficacy of low-doses schedules of HBV vaccine by the intradermal (ID) route. The economical analysis (a cost- minimization study) showed that when the prevalence of immune individuals is higher than 11% it is more cost-effective to perform prevaccination screening. This situation was obsemed in the employees group. For students and doctors vaccination without screening was the best approach. Regarding the schedules, 3 doses of HBV vaccine by the intramuscular (IM) route (group A) were compared to first dose by the ID route and second and third doses by the IM route (group B) and to first and second doses by the ID route and the last dose by the IM route (group C). After the third dose, soroconversion rates in groups A and B (92% and 93%, respectively) and geometric mean titers of antiHBs (1278 UI/I and 789.6 UI/l) were similar, and both were different from group A (p< 0.05), showing that alternative vaccination schedules may be cost-effective.

【 授权许可】

Unknown