Protection status against hepatitis B infection assessed fromanti-HBs level, history of vaccination andhistory of infection based on anti-HBc in medical students

1st International Conference on Tropical Medicine and Infectious Diseases (ICTROMI) Faculty of Medicine Universitas Sumatera Utara

Annisa^1,2 ; Zain, L.H.^3 ; Loesnihari, R.^4

Postgraduate Program in Tropical and Health Medicine, Faculty of Medicine, University of Sumatera Utara, Jl. Dr. T. Mansur, Padang Bulan, Medan, Sumatera Utara

20155, Indonesia^1

Department of Microbiology, Faculty of Medicine, University of Muhammadiyah SumateraUtara, Jl. Gedung Arca, Medan, Sumatera Utara

20217, Indonesia^2

Departement of Gastroenterohepatology, Haji Adam Malik, General Hospital, Jl. Bunga Lau, Medan Tuntungan, Medan, Sumatera Utara

20136, Indonesia^3

Chief Department of Clinical Pathology, Haji Adam Malik, General Hospital, Jl. Bunga Lau, Medan Tuntungan, Medan, Sumatera Utara

20136, Indonesia^4

关键词: Blood serum;    Educational institutions;    Health care workers;    Hepatitis B virus;    High incidence;    Immune response;    Medical students;    Risk of exposures;   

Others  :  https://iopscience.iop.org/article/10.1088/1755-1315/125/1/012104/pdf
DOI  :  10.1088/1755-1315/125/1/012104

来源: IOP

【 摘 要 】

Hepatitis B virus (HBV) is one of the most contagious pathogens where the risk of exposure is very high among health care workers, especially students in the clerkship. This study describes the protection status by measuring anti-HBs level, history of vaccination, and history of HBV infection in medical students.Forty-four (44) students over 18 years old were randomly selected, interviewed for their vaccination history and then had their blood serum taken for anti-HBs and anti-HBc examinations to determine the protectivity and history of infection.There were 81.8% students without a protective anti-HBs level. Before starting their clerkship, 18.2% students received thevaccination, and only one-fourth formed protective antibody level above 10mIU/mL. Seventeen (38.6%) students had been exposed to HBV(positive anti-HBc), and only six of them showed protective anti-HBs level. None of the students that received vaccine underwent a post-vaccination serological test (PVST) to determine their immune response. These results indicated the vulnerability of medical students to the risk of HBV transmission while performing medical care. With the high incidence of HBV transmission, educational institutions are encouraged to make provisions for vulnerable students to receive a booster and an adequate PVST before their clerkship.