Occurrence of yeasts, pseudomonads and enteric bacteria in the oral cavity of patients undergoing head and neck radiotherapy

Brazilian Journal of Microbiology

Elerson Gaetti-jardim Júnior²  Francisco Isaak Nicolas Ciesielski²  Fátima Regina Nunes De Sousa²  Francisca Nwaokorie¹  Christiane Marie Schweitzer¹  Mario Júlio Avila-campos¹ 

[1] ,Universidade Estadual Paulista Faculdade de Odontologia Departamento de Patologia e Propedêutica ClínicaAraçatuba SP ,Brasil

关键词: Radiotherapy;    Cancer;    Enterobacteriaceae;    Prevalence;   

DOI  :  10.1590/S1517-83822011000300024

来源: SciELO

【 摘 要 】

The aim of this study was to evaluate the occurrence of yeasts, pseudomonads and enteric bacteria in the oral cavity of patients undergoing radiotherapy (RT) for treatment of head and neck cancer. Fifty patients receiving RT were examined before, during and 30 days after RT. Saliva, mucosa, and biofilm samples were collected and microorganisms were detected by culture and polymerase chain reaction (PCR). The most prevalent yeasts in patients submitted to RT were Candida albicans, C. tropicalis, C. krusei, C. glabrata and C. parapsilosis. Citrobacter, Enterobacter, Enterococcus, Klebsiella, Proteus, and Pseudomonas were the most frequently cultivated bacteria. Before RT, targeted bacteria were cultivated from 22.2% of edentulous patients and 16.6% of dentate patients; 30 days after RT, these microorganisms were recovered from 77.8% edentulous and 46.8% dentate patients. By PCR, these microorganisms were detected from all edentulous patients, 78.1% of dentate patients. The presence of Gram-negative enteric roads and fungi was particularly frequent in patients presenting mucositis level III or IV. Modifications in the oral environment due to RT treatment seem to facilitate the colonization of oral cavity by members of family Enterobacteriaceae, genera Enterococcus and Candida.

【 授权许可】

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