Brazilian Journal of Microbiology | |
Selection of 5-fluorocytosine-resistant mutants from an Aspergillus niger citric acid-producing strain | |
Ana Paula De F. Conte1  José M. Marin2  | |
[1] ,Faculdade de Ciências Farmacêuticas de Ribeirão PretoSão Paulo SP ,Brasil | |
关键词: Aspergillus niger; citric acid; 5-fluorocytosine; Aspergillus niger; ácido cítrico; 5-fluorocitosina; | |
DOI : 10.1590/S1517-83822003000100001 | |
来源: SciELO | |
【 摘 要 】
Mutants of Aspergillus niger N402, induced by UV mutagenesis, were selected and tested for resistance or sensitivity to 5-fluorocytosine. Some mutants showed increased citric acid production, which did not correlate with the intracellular amount of protein or ammonium ion. The resistance to 5-fluorocytosine proved to be a rational approach for isolation of new mutants with improved production of citric acid. The best mutant (FR13) accumulated double the amount of citric acid produced by the parental strain.
【 授权许可】
CC BY-NC
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