Acquired hemoglobin H disease in a patient with aplastic anemia evolving into acute myeloid leukemia

Sao Paulo Medical Journal

Maria Stella Figueiredo¹  Perla Vicari¹  Eliza Yuriko Sugano Kimura¹  Sandra Vallin Antunes¹  Mihoko Yamamoto¹ 

[1] ,Universidade Federal de São Paulo Escola Paulista de Medicina São Paulo,Brazil

关键词: Hemoglobin H;    Disease;    Aplastic anemia;    Myeloid leukemia;    Myelodysplastic syndromes;    Doença;    Hemoglobina H;    Anemia aplástica;    Leucemia mielóide;    Síndromes mielodisplásicas;   

DOI  :  10.1590/S1516-31802004000600009

来源: SciELO

【 摘 要 】

CONTEXT: The prognosis of severe aplastic anemia has improved since the introduction of bone marrow transplantation and treatment with antithymocyte globulin. In contrast to the success of these protocols, studies with long term follow-up have shown the occurrence of clonal diseases such as paroxysmal nocturnal hemoglobinuria, myelodysplastic syndrome and acute leukemia in aplastic anemia. CASE REPORT: We report the first case of a Brazilian patient with aplastic anemia who developed myelodysplastic syndrome and acute myeloid leukemia showing acquired hemoglobin H and increased fetal hemoglobin.

【 授权许可】

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