Cardiovascular risk in individuals with depression

Revista da Associação Médica Brasileira

Danielle Bivanco-lima²  Itamar De Souza Santos¹  Ana Maria Cortez Vannucchi²  Manoel Carlos Sampaio De Almeida Ribeiro¹ 

[1] ,Irmandade da Santa Casa de Misericórdia de São Paulo Centro de Saúde Escola Barra Funda Dr. Alexandre Vranjac São Paulo SP ,Brazil

关键词: Cardiovascular disease;    Risk factors;    Depressive disorder;    Depression;    Doença cardiovascular;    Fatores de risco;    Transtornos depressivos;    Depressão;   

DOI  :  10.1016/j.ramb.2012.12.006

来源: SciELO

【 摘 要 】

Depression and cardiovascular diseases (CVD) are both common illnesses. Several studies demonstrated that depressed individuals have higher mortality compared to age-and gender-matched population, with an excess of cardiovascular deaths. There is a bidirectional association between depression and CVD. Several factors can interact and influence this relationship: poverty and social inequality, reduced accessibility to health care, biological alterations (as reduced heart rate variability, endothelial dysfunction, increased inflammation and platelet function, and hyperactivity of hypothalamic-pituitary-adrenal axis), side effects of psychiatric medication, lower adherence to medical treatments, and higher frequency of cardiovascular risk factors (higher tobacco use, physical inactivity, obesity, diabetes mellitus). This article aims to update the current evidence of the possible mechanisms involved in the association between depression and CVD.

【 授权许可】

CC BY-NC   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License