Cardiovascular complications in the acquired immunodeficiency syndrome

Revista da Associação Médica Brasileira

Giuseppe Barbaro²  Erika Ferrari Rafael Da Silva¹ 

[1] ,Universidade La Sapienza Policlínica Umberto Primo Departamento de Fisiopatologia MédicaRoma,Itália

关键词: HIV;    Acquired Immunodeficiency Syndrome;    Cardiovascular Diseases;    HIV-Associated Lipodystrophy;    Syndrome Highly Active Antiretroviral Therapy;    HIV;    Doenças cardiovasculares;    Síndrome de Imunodeficiência Adquirida;    Lipodistrofia;    Terapia antirretroviral de alta atividade;   

DOI  :  10.1590/S0104-42302009000500031

来源: SciELO

【 摘 要 】

The introduction of highly active antiretroviral therapy (HAART) has significantly improved the clinical outcome of HIV disease, with increased survival rates. However, the introduction of HAART has generated a contrast in the cardiac manifestations of AIDS. In developed countries, we observed an approximate 30% reduction in the prevalence of HIV-associated cardiomyopathy, possibly related to a reduction of opportunistic infections and myocarditis. In developing countries, however, where the availability of HAART is limited and the pathogenic impact of nutritional factors is significant, we observed an increase of approximately 32% in the prevalence of HIV-associated cardiomyopathy and a related high mortality rate from congestive heart failure. Also, some HAART regimens in developed countries, especially those including protease inhibitors, have been shown to cause, in a high proportion of HIV-infected patients, a iatrogenic metabolic syndrome (HIV-lipodystrophy syndrome).This is associated with an increased risk of atherosclerosis-related cardiovascular events even in young HIV-infected people. A better understanding of the molecular mechanisms responsible for this syndrome will lead to the discovery of new drugs that will reduce cardiovascular risk in HIV-infected patients receiving HAART.

【 授权许可】

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