Identification of multi-drug resistance gene (MDR1) in equine ileum

Ciência Rural

Cláudio Corrêa Natalini¹  Renata Lehn Linardi¹ 

[1] ,Louisiana State University Departament of Veterinary Clinical Sciences Baton Rouge LA ,USA

关键词: molecular biology;    opioids;    equine;    gene;    MDR1;    ABCB1;    biologia molecular;    opióides;    eqüino;    gene;    MDR1;    ABCB1;   

DOI  :  10.1590/S0103-84782006000100048

来源: SciELO

【 摘 要 】

P-glycoprotein (P-gp) is a membrane transporter encoded in the Multi-drug Resistance (MDR1) gene expressed in several normal tissues and over expressed in tumor cells. P-gp was already identified in different species but not yet in equine. MDR1 gene and P-gp are able to interfere with bioavailability and disposition of several drugs, altering pharmacokinetic and pharmacodinamic of drugs. The presence of the MDR1 and P-gp in the central nervous system blocks the entry of certain drugs in this tissue and reduces drug absorption and enhances drug elimination when P-gp and MDR1 are presented in the gastrointestinal tract. This study showed that the MDR1 gene is present in equine ileum. Future studies on the impact of the P-glycoprotein encoded gene MDR1 on drugs pharmacologic effects in horses are granted.

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