Identification of multi-drug resistance gene (MDR1) in equine ileum

Ciência Rural

Natalini, Cláudio Corrêa¹  Linardi, Renata Lehn¹ 

[1] Louisiana State University, Baton Rouge, USA

关键词: molecular biology;    opioids;    equine;    gene;    MDR1;    ABCB1;   

DOI  :  10.1590/S0103-84782006000100048

学科分类：农业科学（综合）

来源: Universidade Federal de Santa Maria * Centro de Ciencias Rurais

【 摘 要 】

P-glycoprotein (P-gp) is a membrane transporter encoded in the Multi-drug Resistance (MDR1) gene expressed in several normal tissues and over expressed in tumor cells. P-gp was already identified in different species but not yet in equine. MDR1 gene and P-gp are able to interfere with bioavailability and disposition of several drugs, altering pharmacokinetic and pharmacodinamic of drugs. The presence of the MDR1 and P-gp in the central nervous system blocks the entry of certain drugs in this tissue and reduces drug absorption and enhances drug elimination when P-gp and MDR1 are presented in the gastrointestinal tract. This study showed that the MDR1 gene is present in equine ileum. Future studies on the impact of the P-glycoprotein encoded gene MDR1 on drugs pharmacologic effects in horses are granted.

【 授权许可】

CC BY-NC