Ciência Rural | |
Identification of multi-drug resistance gene (MDR1) in equine ileum | |
Natalini, Cláudio Corrêa1  Linardi, Renata Lehn1  | |
[1] Louisiana State University, Baton Rouge, USA | |
关键词: molecular biology; opioids; equine; gene; MDR1; ABCB1; | |
DOI : 10.1590/S0103-84782006000100048 | |
学科分类:农业科学(综合) | |
来源: Universidade Federal de Santa Maria * Centro de Ciencias Rurais | |
【 摘 要 】
P-glycoprotein (P-gp) is a membrane transporter encoded in the Multi-drug Resistance (MDR1) gene expressed in several normal tissues and over expressed in tumor cells. P-gp was already identified in different species but not yet in equine. MDR1 gene and P-gp are able to interfere with bioavailability and disposition of several drugs, altering pharmacokinetic and pharmacodinamic of drugs. The presence of the MDR1 and P-gp in the central nervous system blocks the entry of certain drugs in this tissue and reduces drug absorption and enhances drug elimination when P-gp and MDR1 are presented in the gastrointestinal tract. This study showed that the MDR1 gene is present in equine ileum. Future studies on the impact of the P-glycoprotein encoded gene MDR1 on drugs pharmacologic effects in horses are granted.
【 授权许可】
CC BY-NC
【 预 览 】
Files | Size | Format | View |
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RO201911300912640ZK.pdf | 411KB | download |