Design and cytotoxic evaluation of new annonaceous acetogenin analogues

Journal of the Brazilian Chemical Society

Jürgen Krauss¹  Franz Bracher¹  Katrin Synowitz¹  Doris Unterreitmeier¹ 

[1] ,Universität München Zentrum für Pharmaforschung Ludwig-Maximilians Department PharmazieMunich,Germany

关键词: Sonogashira reaction;    Grignard reaction;    cytotoxicity;   

DOI  :  10.1590/S0103-50532007000400004

来源: SciELO

【 摘 要 】

Analogues of annonaceous acetogenins were built up from 5-iodofuran-2-carbaldehyde and undec-10-ynoic acid or undec-10-ynol by a Sonogashira reaction, followed by a Grignard reaction and a mercury catalysed hydratisation. The cytotoxicity was evaluated with MTT assay ((3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide colorimetric assay for measuring cellular proliferation) against HL cells and at the National Cancer Institute (NCI).

【 授权许可】

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