期刊论文详细信息
| Journal of the Brazilian Chemical Society | |
| Design and cytotoxic evaluation of new annonaceous acetogenin analogues | |
| Krauss, Jürgen1 Universität München, Munich, Germany1 Synowitz, Katrin1 Bracher, Franz1 Unterreitmeier, Doris1 | |
| 关键词: Sonogashira reaction; Grignard reaction; cytotoxicity; | |
| DOI : 10.1590/S0103-50532007000400004 | |
| 学科分类：化学（综合） | |
| 来源: SciELO | |
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【 摘 要 】
Analogues of annonaceous acetogenins were built up from 5-iodofuran-2-carbaldehyde and undec-10-ynoic acid or undec-10-ynol by a Sonogashira reaction, followed by a Grignard reaction and a mercury catalysed hydratisation. The cytotoxicity was evaluated with MTT assay ((3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide colorimetric assay for measuring cellular proliferation) against HL cells and at the National Cancer Institute (NCI).
【 授权许可】
Unknown
【 预 览 】
| Files | Size | Format | View |
|---|---|---|---|
| RO201912050580187ZK.pdf | 74KB |  download |
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