Microwave-assisted synthesis of novel 5-trichloromethyl-4,5-dihydro-1H-1-pyrazole methyl esters under solvent free conditions

Journal of the Brazilian Chemical Society

Marcos A. P. Martins¹  Paulo Beck¹  Pablo Machado¹  Sergio Brondani¹  Sidnei Moura¹  Nilo Zanatta¹  Helio G. Bonacorso¹  Alex F. C. Flores¹ 

[1] ,Universidade Federal de Santa Maria Departamento de Química Núcleo de Química de Heterociclos (NUQUIMHE)Santa Maria RS ,Brazil

关键词: pyrazoles;    enones;    microwave irradiations;    green chemistry;   

DOI  :  10.1590/S0103-50532006000200027

来源: SciELO

【 摘 要 】

Twelve novel 5-trichloromethyl-4,5-dihydro-1H-1-pyrazole ethyl esters have been synthesized in good yields (70-98%) by using environmentally benign microwave induced techniques. The compounds were synthesized from the cyclocondensation of 1,1,1-trichloro-4-alkoxy-3-alken-2-ones [CCl3C(O)C(R²)=C(R¹ )OR, where R, R² = H, alkyl; R¹ = H, alkyl and aryl] with hydrazine methyl carboxylate. The advantages obtained by the using of microwave irradiation under solvent-free conditions, rather than a conventional method, were demonstrated.

【 授权许可】

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