Microwave-assisted synthesis of novel 5-trichloromethyl-4,5-dihydro-1H-1-pyrazole methyl esters under solvent free conditions

Journal of the Brazilian Chemical Society

Moura, Sidnei¹  Flores, Alex F. C.¹  Zanatta, Nilo¹  Machado, Pablo¹  Bonacorso, Helio G.¹  Martins, Marcos A. P.¹  Beck, Paulo¹  Brondani, Sergio¹  Universidade Federal de Santa Maria, Santa Maria, Brazil¹ 

关键词: pyrazoles;    enones;    microwave irradiations;    green chemistry;   

DOI  :  10.1590/S0103-50532006000200027

学科分类：化学（综合）

来源: SciELO

【 摘 要 】

Twelve novel 5-trichloromethyl-4,5-dihydro-1H-1-pyrazole ethyl esters have been synthesized in good yields (70–98%) by using environmentally benign microwave induced techniques. The compounds were synthesized from the cyclocondensation of 1,1,1-trichloro-4-alkoxy-3-alken-2-ones [CCl3C(O)C(R2)=C(R1 )OR, where R, R2 = H, alkyl; R1 = H, alkyl and aryl] with hydrazine methyl carboxylate. The advantages obtained by the using of microwave irradiation under solvent-free conditions, rather than a conventional method, were demonstrated.

【 授权许可】

Unknown