Low-level laser therapy modulates musculoskeletal loss in a skin burn model in rats

Acta Cirurgica Brasileira

Francielle Martins¹  Ana Cláudia Muniz Rennó¹  Flávia De Oliveira¹  Natália Peruchi Minatel¹  Jeferson André Bortolin¹  Hananiah Tardivo Quintana¹  Mariana Chaves Aveiro¹ 

关键词: Burns;    Laser Therapy;    Low-Level;    MyoD Protein;    Rats;   

DOI  :  10.1590/S0102-86502015002000002

来源: SciELO

【 摘 要 】

PURPOSE: To investigate the effectiveness of low-level laser therapy (LLLT) on gastrocnemius muscle morphology and Myod imunoexpression in a model of dorsal burn in rats. METHODS: Sixteen male Wistar rats were distributed into two groups: control group (CG): rats submitted to scald burn injury without treatment and laser treated group (LG): rats submitted to scald burn injury and treated with laser therapy. Fourteen days post-surgery, gastrocnemius muscle was evaluated being the specimens stained with HE and morphometric data was evaluated. MyoD expression was assessed by immunohistochemistry. RESULTS: The results showed that laser treated animals presented more organized tissue morphology compared to the non-treated animals, with a higher number of nucleus in the fibers. Also, the cross sectional area of the fibers and the MyoD immunoexpression in the laser treated groups was higher. CONCLUSION: Low-level laser therapy had positive effects on gastrocnemius muscle, improving tissue muscle morphology, increasing cross sectional area and MyoD immunoexpression.

【 授权许可】

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