Improvement of bone repair in diabetic rats subjected to ƛ780 nm low-level laser therapy

Acta Cirurgica Brasileira

Marismar Fernandes Do Nascimento¹  Bernadeth Moda De Almeida¹  John Lennon Silva Cunha¹  Rafael Barreto Vieira Valois¹  Juliana Campos Pinheiro¹  Maria Amália Gonzaga Ribeiro¹  Sonia Oliveira Lima¹  Ricardo Luiz Cavalcanti De Albuquerque-júnior¹ 

关键词: Laser Therapy;    Low-Level;    Diabetes Mellitus;    Experimental;    Osteogenesis;    Alkaline Phosphatase;    Rats;   

DOI  :  10.1590/S0102-865020150100000002

来源: SciELO

【 摘 要 】

PURPOSE:To investigate the effect of low-level laser therapy on bone healing in diabetic rats.METHODS:Bone cavities (19 mm diameter) were performed in the femur of 72 alloxan-induced diabetic rats, which were assigned into four groups: CTR (non-diabetic control), DBT (diabetic) CTRL (non-diabetic irradiated) and DBTL (diabetic irradiated). Low-level laser therapy was performed every 48h for seven days. Animals were euthanized at seven, 18 and 30 days. Alkaline phosphatase serum levels and bone repair were analyzed.RESULTS:Low-level laser therapy significantly increased alkaline phosphatase in at seven and 18 days (p<0.001), and improved bone healing at seven (p<0.01), 18 (p<0.05) and 30 (p<0.01) in diabetic animals. In addition, bone healing in irradiated diabetic group was statistically similar to control group at 30 days (p>0.05).CONCLUSION: Low-level laser therapy increased the serum levels of alkaline phosphatase and improved bone healing in alloxan-induced diabetic rats.

【 授权许可】

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