Lung morphology and growth of rats exposed to tobacco smoke and alcohol

Acta Cirurgica Brasileira

Karla Luciana Magnani¹  Daniele Cristina Cataneo²  Vera Luiza Capelozzi¹  Julio Defaveri²  Erica Nishida Hasimoto¹  Antônio José Maria Cataneo² 

[1] ,UNESPSao Paulo SP ,Brazil

关键词: Alcoholism;    Smoking;    Lung Diseases;    Rats;    Alcoolismo;    Tabagismo;    Pneumopatias;    Ratos;   

DOI  :  10.1590/S0102-86502012001000004

来源: SciELO

【 摘 要 】

PURPOSE: Investigate the morphological effects of chronic exposure to tobacco smoke inhalation and alcohol consumption on the lungs and on the growth of rats. METHODS: Sixty male Wistar rats were divided into four groups: control, tobacco, alcohol, tobacco + alcohol, for a period of study 260 days. Morphological analysis was conducted by optical and electron microscopy. Rat growth was investigated by measuring the snout-anus length, body mass index and body weight. RESULTS: The three groups exposed to the drugs presented lower growth and lower weight than the control group. The percentages of alveolitis, bronchiolitis and the mean alveolar diameter were greater, particularly in the groups exposed to tobacco smoke, but were not significantly different from the control group. Electron microscopy revealed more intense apoptotic and degenerative lesions in the smoking group, while degenerative lesions in the lamellar bodies were more intense with the association of both drugs. CONCLUSIONS: This experimental model showed morphological alterations observed by electron microscopy, principally due to tobacco smoke exposure. Alcohol and tobacco hindered the growth of rats, such that tobacco showed a greater effect on body length and alcohol on body weight.

【 授权许可】

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