Proliferative effect of the aqueous extract of Hyptis pectinata on liver regeneration after partial hepatectomy in rats

Acta Cirurgica Brasileira

Gustavo Barreto Melo²  Renata Lemos Silva²  Valdinaldo Aragão Melo¹  Ângelo Roberto Antoniolli¹  Paulo Roberto Teixeira Michellone¹  Sérgio Zucoloto¹  Maria Eliza Jordani De Souza¹  Maria Cecília Jordani Gomes¹  Rodrigo Borges Correia¹  Orlando De Castro-e-silva¹ 

[1] ,Federal University of Sergipe,Brazil

关键词: Liver Regeneration;    Partial Hepatectomy;    Hyptis pectinata;    Plant;    Regeneração Hepática;    Hepatectomia Parcial;    Hyptis pectinata;    Planta;   

DOI  :  10.1590/S0102-86502006000700008

来源: SciELO

【 摘 要 】

PURPOSE: This study was carried out to assess the effects of the aqueous extract of Hyptis pectinata leaves on liver regeneration and on serum enzymes (AST, ALT and gamma-GT) after 67% partial hepatectomy in rats. METHODS: AST, ALT and gamma-GT, were determined by conventional procedures using a spectrophotometer (Model E2250-CELM). Liver regeneration was evaluated by immunohistochemical staining for proliferating cell nuclear antigen (PCNA). RESULTS:Oral pretreatment during 4 days at 100 mg/kg increased liver regeneration index. At 200 mg/kg, AST level was statistically decreased in comparison to the group submited to distilled water administration. The other enzymes assessed disclosed no difference when all groups were compared. CONCLUSION: The present study shows that the aqueous extract of Hyptis pectinata leaves contains some biological active principles that stimulate liver regeneration at 100 mg/kg and cause slight hepatic protection at 200 mg/kg.

【 授权许可】

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