Effect of the aqueous extract of Sida cordifolia on liver regeneration after partial hepatectomy

Acta Cirurgica Brasileira

Renata Lemos Silva²  Gustavo Barreto De Melo²  Valdinaldo Aragão De Melo¹  Ângelo Roberto Antoniolli¹  Paulo Roberto Teixeira Michellone¹  Sérgio Zucoloto¹  Maria Aparecida Neves Cardoso Picinato¹  Clarice Fleury Fina Franco¹  Gustavo De Assis Mota¹  Orlando De Castro E Silva¹ 

[1] ,Federal University of Sergipe,Brazil

关键词: Partial Hepatectomy;    Liver Regeneration;    Sida cordifolia;    Medicinal Plant;    Hepatectomia Parcial;    Regeneração Hepática;    Sida cordifolia;    Planta Medicinal;   

DOI  :  10.1590/S0102-86502006000700009

来源: SciELO

【 摘 要 】

PURPOSE: The use of medicinal plants for the treatment of human diseases has increased worldwide. Many of them are used by oral administration and, after absorption, may affect many organs. Therefore, this study aimed at assessing the effects of the aqueous extract of Sida cordifolia leaves, popularly known in Brazil as "malva-branca", on liver regeneration. METHODS: Twenty rats were divided into four groups: control, Sida100, Sida200 and Sida400 groups. All animals were submitted to oral administration of distilled water, 100, 200 and 400 mg/kg of the aqueous extract of Sida cordifolia, respectively. Immediately after this, they underwent 67% partial hepatectomy. Twenty four hours later, their livers were removed. Hepatic regeneration was assessed by immunohistochemical staining for proliferating cell nuclear antigen (PCNA) using the PC-10 monoclonal antibody. RESULTS: Sida100 and Sida200 groups disclosed higher liver regeneration indices than control group (p<0.001 and p<0.05, respectively). CONCLUSION: The aqueous extract of Sida cordifolia stimulates liver regeneration after 67% partial hepatectomy in rats.

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