Antinociceptive effects of an extract, fraction and an isolated compound of the stem bark of Maytenus rigida

Revista Brasileira de Farmacognosia

Marina V. Martins²  Charles Dos S. Estevam¹  André L. L. M. Santos¹  Antonio S. Dias¹  Yolanda K. Cupertino-da-silva²  João X. Araújo-júnior¹  Ana Luisa P. Miranda¹  Eliezer J. Barreiro¹  Cosimo Pizza¹  Sonia Piacente¹  Paola Montoro¹  Lucindo J. Quintans-júnior¹  Brancilene S. Araujo¹  Magna S. Alexandre-moreira²  Antônio E.g. Sant'ana¹ 

[1] ,Universidade Federal de Alagoas Instituto de Ciências Biológicas e da Saúde Setor de Fisiologia e Farmacologia,Brazil

关键词: anti-inflammatory activity;    antinociceptive activity;    Maytenus rigida;    Celastraceae;    (-)-4'-methylepigallocatechin;   

DOI  :  10.1590/S0102-695X2012005000007

来源: SciELO

【 摘 要 】

The antinociceptive activity of the Maytenus rigida Mart. (Celastraceae) ethanol extract and its ethyl acetate fraction as well as of (-)-4'-methylepigallocatechin (1), a previously isolated compound, was demonstrated in vivo. ED50 for 1 in the writhing test was 14.14 mg/kg. The acetic acid-induced writhing was inhibited by 98.4, 84.4, and 58.3%, respectively, when mice were treated with the ethanol extract, ethyl acetate fraction, and 1. In the hot plate test, mice pretreated with 1 showed significantly increased reaction times (60-89%). Oral administration of 1 significantly inhibited first and second phases of the formalin-induced pain (50 and 26.5%, respectively), whereas indomethacin inhibited only the second phase of the test (41.2%). Ethanol extract and its fraction showed effects on inflammatory pain, while neurogenic and inflammatory pain suppression by 1 is a strong indication of the presence of both central and peripheral effects and suggests its analgesic and anti-inflammatory potential.

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