Pharmacological studies of ethanolic extracts of Maytenus rigida Mart (Celastraceae) in animal models

Revista Brasileira de Farmacognosia

Agra, Maria de Fátima¹  Batista, Leônia Maria¹  Costa, Viviam Bruna Machado¹  Santos, Vanda Lucia dos¹  Silva, Bagnólia Araújo da¹  Universidade Federal da Paraíba, João Pessoa, Brazil¹ 

关键词: Maytenus rigida;    Celastraceae;    anti-inflammatory;    antiulcer;    anti-diarrhoeal.;   

DOI  :  10.1590/S0102-695X2007000300006

来源: Sociedade Brasileira de Farmacognosia

【 摘 要 】

The crude ethanol extract (EEOH) of the bark of Maytenus rigida Mart (Celastraceae) a plant used in Brazil herbal traditional medicine, was tested for anti-inflammatory, antiulcer and antidiarrhoeal activities in animal models. No acute toxicological sign was observed in animals treated with the highest dose (5000 mg/kg, p.o. or 2000 mg/kg i.p.) of EEOH. The extract doses of 250, 500 or 750 mg/kg revealed a significant inhibitory effect (P < 0,01) in carrageenin-induced rat paw oedema and exhibited ulcer-protective properties against ethanol-induced ulceration in rats. An anti-diarrhoeal activity (P < 0.01) was also observed in castor-oil-induced diarrhoeal in mice. The intestinal transit was significantly (P < 0.01) reduced, however the pretreatment did not reduce the weight of intestinal contents. These results support the popular applications of Maytenus rigida for the treatment of inflammation, ulcer and diarrhoea in Brazil herbal traditional medicine.

【 授权许可】

Unknown