Pharmacological studies of ethanolic extracts of Maytenus rigida Mart (Celastraceae) in animal models

Revista Brasileira de Farmacognosia

Vanda Lucia Dos Santos¹  Viviam Bruna Machado Costa¹  Maria De Fátima Agra¹  Bagnólia Araújo Da Silva¹  Leônia Maria Batista¹ 

[1] ,Universidade Federal da Paraíba Laboratório de Tecnologia Farmacêutica João Pessoa PB ,Brazil

关键词: Maytenus rigida;    Celastraceae;    anti-inflammatory;    antiulcer;    anti-diarrhoeal;    Maytenus rigida;    Celastraceae;    antiinflamatória;    antiúlcera;    antidiarréica;   

DOI  :  10.1590/S0102-695X2007000300006

来源: SciELO

【 摘 要 】

The crude ethanol extract (EEOH) of the bark of Maytenus rigida Mart (Celastraceae) a plant used in Brazil herbal traditional medicine, was tested for anti-inflammatory, antiulcer and antidiarrhoeal activities in animal models. No acute toxicological sign was observed in animals treated with the highest dose (5000 mg/kg, p.o. or 2000 mg/kg i.p.) of EEOH. The extract doses of 250, 500 or 750 mg/kg revealed a significant inhibitory effect (P < 0,01) in carrageenin-induced rat paw oedema and exhibited ulcer-protective properties against ethanol-induced ulceration in rats. An anti-diarrhoeal activity (P < 0.01) was also observed in castor-oil-induced diarrhoeal in mice. The intestinal transit was significantly (P < 0.01) reduced, however the pretreatment did not reduce the weight of intestinal contents. These results support the popular applications of Maytenus rigida for the treatment of inflammation, ulcer and diarrhoea in Brazil herbal traditional medicine.

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