Antinociceptive effects of an extract, fraction and an isolated compound of the stem bark of Maytenus rigida

Revista Brasileira de Farmacognosia

Araujo, Brancilene S.¹  Cupertino-da-Silva, Yolanda K.¹  Dias, Antonio S.¹  Universidade Federal do Rio de Janeiro, Brazil¹  Alexandre-Moreira, Magna S.¹  Sant'Ana, Antônio E.G.¹  Montoro, Paola¹  Santos, André L. L. M.¹  Martins, Marina V.¹  Estevam, Charles dos S.¹  Universidade Federal de Alagoas, Brazil¹  Araújo-Júnior, João X.¹  Universidade Federal de Sergipe, Brazil¹  Miranda, Ana Luisa P.¹  Università Degli Studi di Salerno, Italy¹  Piacente, Sonia¹  Barreiro, Eliezer J.¹  Pizza, Cosimo¹  Quintans-Júnior, Lucindo J.¹ 

关键词: anti-inflammatory activity;    antinociceptive activity;    Maytenus rigida;    Celastraceae;    (-)-4'-methylepigallocatechin;   

DOI  :  10.1590/S0102-695X2012005000007

来源: Sociedade Brasileira de Farmacognosia

【 摘 要 】

The antinociceptive activity of the Maytenus rigida Mart. (Celastraceae) ethanol extract and its ethyl acetate fraction as well as of (-)-4'-methylepigallocatechin (1), a previously isolated compound, was demonstrated in vivo. ED50 for 1 in the writhing test was 14.14 mg/kg. The acetic acid-induced writhing was inhibited by 98.4, 84.4, and 58.3%, respectively, when mice were treated with the ethanol extract, ethyl acetate fraction, and 1. In the hot plate test, mice pretreated with 1 showed significantly increased reaction times (60-89%). Oral administration of 1 significantly inhibited first and second phases of the formalin-induced pain (50 and 26.5%, respectively), whereas indomethacin inhibited only the second phase of the test (41.2%). Ethanol extract and its fraction showed effects on inflammatory pain, while neurogenic and inflammatory pain suppression by 1 is a strong indication of the presence of both central and peripheral effects and suggests its analgesic and anti-inflammatory potential.

【 授权许可】

Unknown