Anticonvulsant evaluation of Rauvolfia ligustrina Willd. ex Roem. & Schult., Apocynaceae, in rodents

Revista Brasileira de Farmacognosia

Lucindo J. Quintans-júnior²  Jullyana S. Siqueira¹  Mônica S. Melo²  Davi A. Silva¹  Liana C. S. L. Morais¹  Maria De Fátima V. Souza¹  Reinaldo N. Almeida¹ 

[1] ,Universidade Federal de Sergipe Campus Universitário ''Prof. Aloísio de Campos'' Departamento de FisiologiaSão Cristóvão SE ,Brazil

关键词: Rauvolfia ligustrina;    pentylenetetrazole;    picrotoxin;    kindling;    flumazenil;    Rauvolfia ligustrina;    pentilenotetrazol;    picrotoxina;    abrasamento;    flumazenil;   

DOI  :  10.1590/S0102-695X2010000100012

来源: SciELO

【 摘 要 】

The Aim of this study was to evaluated the effects of the ethanol extract of Rauvolfia ligustrina Willd. ex Roem. & Schult., Apocynaceae, roots (EER) in animal models of epilepsy. The EER increased the latency for convulsions significantly different from control (p<0,05) and in the PTZ induced convulsions test on 62,5 mg/kg (i.p.) decreased mortality. This effect was blocked by flumazenil administration, suggesting an involvement of GABAergic system in the anticonvulsant activity of EER. The EER had a moderate effect only against PIC- or STR-induced convulsions at doses 125 and 250 mg/kg. But in the MES test it did not demonstrate effect on this animal model. Therefore, the EER reduced the development of PTZ-induced kindling in both experimental groups. It also significantly (p<0.05) decreased the latency for convulsions and reduced its percentage. Our results suggest that EER owns anticonvulsant property.

【 授权许可】

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