Anticonvulsant properties of the total alkaloid fraction of Rauvolfia ligustrina Roem. et Schult. in male mice

Revista Brasileira de Farmacognosia

Lucindo J. Quintans-júnior²  Davi A. Silva¹  Jullyana S. Siqueira¹  Maria De Fátima V. De Souza¹  Reinaldo N. Almeida¹  René G. C. Silva-júnior¹ 

[1] ,Universidade Federal de Sergipe Departamento de Fisiologia São Cristovão SE ,Brazil

关键词: Rauvolfia ligustrina;    anticonvulsant activity;    pentylenetetrazol;    picrotoxin;    maximal electroshock;    Rauvolfia ligustrina;    anticonvulsivante;    pentilenotetrazol;    picrotoxina;    eletrochoque auricular;   

DOI  :  10.1590/S0102-695X2007000200007

来源: SciELO

【 摘 要 】

Rauvolfia ligustrina Roem et. Schult (Apocynaceae), commonly known as "paratudo" and "arrebenta-boi" is a small tree found in Brazilian Northeastern. Previous studies have demonstrated depressant and anticonvulsant properties of the ethanol extract of Rauvolfia ligustrina. The aim of the present study was the determination of the lethal dose 50% (LD50) and the effects of total alkaloid fraction (TAF) of the aerial parts of R. ligustrina in animal models of convulsion. It was found that the acute toxicity of TAF was 127.8 (112.5-145.2) mg/kg (i.p.) in mice. TAF (20 mg/kg, ip) significantly increased (p < 0.05) the latencies of clonic seizures induced by pentylenetetrazol (PTZ) and picrotoxin (PIC). However, TAF did not protect the animals in maximal electroshock (MES) induced seizures. These results suggest that TAF of R. ligustrina possesses anticonvulsant properties.

【 授权许可】

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