Anticonvulsant evaluation of Rauvolfia ligustrina Willd. ex Roem. & Schult., Apocynaceae, in rodents

Revista Brasileira de Farmacognosia

Morais, Liana C. S. L.¹  Souza, Maria de Fátima V.¹  Universidade Federal de Sergipe, São Cristóvão, Brazil¹  Universidade Federal da Paraíba, Paraíba, Brazil¹  Silva, Davi A.¹  Almeida, Reinaldo N.¹  Melo, Mônica S.¹  Quintans-Júnior, Lucindo J.¹  Siqueira, Jullyana S.¹ 

关键词: Rauvolfia ligustrina;    pentylenetetrazole;    picrotoxin;    kindling;    flumazenil.;   

DOI  :  10.1590/S0102-695X2010000100012

来源: Sociedade Brasileira de Farmacognosia

【 摘 要 】

The Aim of this study was to evaluated the effects of the ethanol extract of Rauvolfia ligustrina Willd. ex Roem. & Schult., Apocynaceae, roots (EER) in animal models of epilepsy. The EER increased the latency for convulsions significantly different from control (p<0,05) and in the PTZ induced convulsions test on 62,5 mg/kg (i.p.) decreased mortality. This effect was blocked by flumazenil administration, suggesting an involvement of GABAergic system in the anticonvulsant activity of EER. The EER had a moderate effect only against PIC- or STR-induced convulsions at doses 125 and 250 mg/kg. But in the MES test it did not demonstrate effect on this animal model. Therefore, the EER reduced the development of PTZ-induced kindling in both experimental groups. It also significantly (p<0.05) decreased the latency for convulsions and reduced its percentage. Our results suggest that EER owns anticonvulsant property.

【 授权许可】

Unknown