Anticonvulsant properties of the total alkaloid fraction of Rauvolfia ligustrina Roem. et Schult. in male mice

Revista Brasileira de Farmacognosia

Silva-Júnior, René G. C.¹  Universidade Federal da Paraíba, Paraíba, Brazil¹  Universidade Federal de Sergipe, São Cristovão, Brazil¹  Silva, Davi A.¹  Souza, Maria de Fátima V. de¹  Almeida, Reinaldo N.¹  Quintans-Júnior, Lucindo J.¹  Siqueira, Jullyana S.¹  Universidade Federal do Vale do São Francisco, Petrolina, Brazil¹ 

关键词: Rauvolfia ligustrina;    anticonvulsant activity;    pentylenetetrazol;    picrotoxin;    maximal electroshock.;   

DOI  :  10.1590/S0102-695X2007000200007

来源: Sociedade Brasileira de Farmacognosia

【 摘 要 】

Rauvolfia ligustrina Roem et. Schult (Apocynaceae), commonly known as "paratudo" and "arrebenta-boi" is a small tree found in Brazilian Northeastern. Previous studies have demonstrated depressant and anticonvulsant properties of the ethanol extract of Rauvolfia ligustrina. The aim of the present study was the determination of the lethal dose 50% (LD50) and the effects of total alkaloid fraction (TAF) of the aerial parts of R. ligustrina in animal models of convulsion. It was found that the acute toxicity of TAF was 127.8 (112.5-145.2) mg/kg (i.p.) in mice. TAF (20 mg/kg, ip) significantly increased (p < 0.05) the latencies of clonic seizures induced by pentylenetetrazol (PTZ) and picrotoxin (PIC). However, TAF did not protect the animals in maximal electroshock (MES) induced seizures. These results suggest that TAF of R. ligustrina possesses anticonvulsant properties.

【 授权许可】

Unknown