Pharmacological effects of the monoterpene alpha,beta-epoxy-carvone in mice

Revista Brasileira de Farmacognosia

Damião P. De Sousa²  Franklin F. F. Nóbrega¹  Fladmir S. Claudino¹  Reinaldo N. De Almeida¹  José R. Leite¹  Rita Mattei¹ 

[1] ,Universidade Federal de Sergipe Departamento de Fisiologia São Cristóvão SE ,Brazil

关键词: Pharmacological effects;    essential oil;    monoterpene;    alpha;    beta-epoxy-carvone;    mice;    Efeito farmacológico;    óleo essencial;    monoterpeno;    alfa;    beta-epóxi-carvona;    camundongos;   

DOI  :  10.1590/S0102-695X2007000200006

来源: SciELO

【 摘 要 】

The monoterpene alpha,beta-epoxy-carvone (EC) in doses of 200, 300 or 400 mg/kg injected by i.p. route in mice caused a significant decrease in the motor activity of animals when compared with the control group, up to 120 minutes after the administration. The doses of 300 or 400 mg/kg had induced a significant increase of in the sleeping time of animals not having modified, however, the latency. The EC in the dose of 400 mg/kg reduced the remaining time of the animals on the rotating rod (Rotarod test). These results suggest a possible central effect.

【 授权许可】

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