Revista Brasileira de Farmacognosia | |
Pharmacological effects of the monoterpene alpha,beta-epoxy-carvone in mice | |
Damião P. De Sousa2  Franklin F. F. Nóbrega1  Fladmir S. Claudino1  Reinaldo N. De Almeida1  José R. Leite1  Rita Mattei1  | |
[1] ,Universidade Federal de Sergipe Departamento de Fisiologia São Cristóvão SE ,Brazil | |
关键词: Pharmacological effects; essential oil; monoterpene; alpha; beta-epoxy-carvone; mice; Efeito farmacológico; óleo essencial; monoterpeno; alfa; beta-epóxi-carvona; camundongos; | |
DOI : 10.1590/S0102-695X2007000200006 | |
来源: SciELO | |
【 摘 要 】
The monoterpene alpha,beta-epoxy-carvone (EC) in doses of 200, 300 or 400 mg/kg injected by i.p. route in mice caused a significant decrease in the motor activity of animals when compared with the control group, up to 120 minutes after the administration. The doses of 300 or 400 mg/kg had induced a significant increase of in the sleeping time of animals not having modified, however, the latency. The EC in the dose of 400 mg/kg reduced the remaining time of the animals on the rotating rod (Rotarod test). These results suggest a possible central effect.
【 授权许可】
CC BY-NC-ND
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