Pharmacological effects of the monoterpene alpha,beta-epoxy-carvone in mice

Revista Brasileira de Farmacognosia

Universidade Federal de Sergipe, São Cristóvão, Brazil¹  Leite, José R.¹  Mattei, Rita¹  Universidade Federal de São Paulo, São Paulo, Brazil¹  Nóbrega, Franklin F. F.¹  Almeida, Reinaldo N. de¹  Sousa, Damião P. de¹  Claudino, Fladmir S.¹  Universidade Federal da Paraíba, João Pessoa, Brazil¹ 

关键词: Pharmacological effects;    essential oil;    monoterpene;    a;    b-epoxy-carvone;    mice.;   

DOI  :  10.1590/S0102-695X2007000200006

来源: Sociedade Brasileira de Farmacognosia

【 摘 要 】

The monoterpene a,b-epoxy-carvone (EC) in doses of 200, 300 or 400 mg/kg injected by i.p. route in mice caused a significant decrease in the motor activity of animals when compared with the control group, up to 120 minutes after the administration. The doses of 300 or 400 mg/kg had induced a significant increase of in the sleeping time of animals not having modified, however, the latency. The EC in the dose of 400 mg/kg reduced the remaining time of the animals on the rotating rod (Rotarod test). These results suggest a possible central effect.

【 授权许可】

Unknown