Espectroscopia de Ressonância Magnética Nuclear de 13C no estudo de rotas biossintéticas de produtos naturais

Química Nova

Fernando César De Macedo Júnior¹ 

[1] ,Universidade Estadual de Campinas Instituto de Química Campinas SP ,Brasil

关键词: 13C NMR;    isotopic labeling;    biosynthetic routes;   

DOI  :  10.1590/S0100-40422007000100023

来源: SciELO

【 摘 要 】

During the last five decades, as a result of an interaction between natural product chemistry, synthetic organic chemistry, molecular biology and spectroscopy, scientists reached an extraordinary level of comprehension about the natural processes by which living organisms build up complex molecules. In this context, 13C nuclear magnetic resonance spectroscopy, allied with isotopic labeling, played a determinant role. Nowadays, the widespread use of modern NMR techniques allows an even more detailed picture of the biochemical steps by accurate manipulation of the atomic nuclei. This article focuses on the development of such techniques and their impact on biosynthetic studies.

【 授权许可】

CC BY-NC   
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