13C Nuclear Magnetic Resonance spectroscopy in the studies of biosythetic routes of natural products

Quimica nova

Macedo Júnior, Fernando César de¹ 

[1] Universidade Estadual de Campinas, Campinas, Brasil

关键词: 13C NMR;    isotopic labeling;    biosynthetic routes.;   

DOI  :  10.1590/S0100-40422007000100023

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

During the lastfive decades, as a result of an interaction between natural product chemistry,synthetic organic chemistry, molecular biology and spectroscopy, scientistsreached an extraordinary level of comprehension about the natural processesby which living organisms build up complex molecules. In this context, 13Cnuclear magnetic resonance spectroscopy, allied with isotopic labeling, playeda determinant role. Nowadays, the widespread use of modern NMR techniques allowsan even more detailed picture of the biochemical steps by accurate manipulationof the atomic nuclei. This article focuses on the development of such techniquesand their impact on biosynthetic studies.

【 授权许可】

CC BY