Synthesis of Novel Isochromen-1-one analogues of Etodolac

14th International Conference on Science, Engineering and Technology

自然科学;工业技术

Napoleon, A.A.^1 ; Sharma, Vijay^1 ; Aggile, Kadirappa^1

Department of Chemistry, School of Advanced Sciences, VIT University, Vellore, Tamil Nadu

632014, India^1

关键词: 13C NMR;    Anti-inflammatory drugs;    Bulk drugs;    Etodolac;    Mass spectroscopy;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/263/2/022021/pdf
DOI  :  10.1088/1757-899X/263/2/022021

来源: IOP

【 摘 要 】

In the present work, anti-inflammatory drug based novel isochromen-1-one, their thio and N-methylated analogues were synthesized from the etodolac bulk drug, 1. All the synthesized compounds were purified and successfully characterized by FT-IR,1H NMR,13C NMR and Mass spectroscopy. All the derivatives procured are with remarkable yields from 67-72%.