On cytoadhesion of Plasmodium vivax: raison d'être?

Memórias do Instituto Oswaldo Cruz

Fabio Tm Costa²  Stefanie Cp Lopes²  Mireia Ferrer¹  Juliana A Leite²  Lorena Martin-jaular¹  Maria Bernabeu¹  Paulo A Nogueira¹  Maria Paula G Mourão¹  Carmen Fernandez-becerra¹  Marcus Vg Lacerda¹  Hernando Del Portillo¹ 

[1] ,Universidade Estadual de Campinas Instituto de Biologia Departamento de Genética, Evolução e BioagentesCampinas SP ,Brasil

关键词: Plasmodium vivax;    malaria;    cytoadherence;    severe disease;   

DOI  :  10.1590/S0074-02762011000900010

来源: SciELO

【 摘 要 】

It is generally accepted that Plasmodium vivax, the most widely distributed human malaria parasite, causes mild disease and that this species does not sequester in the deep capillaries of internal organs. Recent evidence, however, has demonstrated that there is severe disease, sometimes resulting in death, exclusively associated with P. vivax and that P. vivax-infected reticulocytes are able to cytoadhere in vitro to different endothelial cells and placental cryosections. Here, we review the scarce and preliminary data on cytoadherence in P. vivax, reinforcing the importance of this phenomenon in this species and highlighting the avenues that it opens for our understanding of the pathology of this neglected human malaria parasite.

【 授权许可】

CC BY   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License