In vitro activity of the clinical pulmonary surfactant Surfacen® against Leishmania amazonensis

Revista do Instituto de Medicina Tropical de São Paulo

Odalys Blanco²  Yuliannis Lugones²  Elaine Díaz²  Lianet Monzote¹ 

[1] ,Centro Nacional de Sanidad Agropecuaria Grupo de Química-Farmacología-Toxicología Mayabeque,Cuba

关键词: Leishmania amazonensis;    Pulmonary surfactant;    Antibiotic activity;    Antimicrobial;    SP-B;   

DOI  :  10.1590/S0036-46652011000400012

来源: SciELO

【 摘 要 】

Surfacen® is an exogenous natural lung surfactant, composed by phospholipids and hydrophobic proteins, which is applied successfully in Newborn Respiratory Distress Syndrome. In this paper, in vitro activity of Surfacen® against Leishmania amazonensis is described. The product showed activity against the amastigote form found in peritoneal macrophages from BALB/c mice, with an IC50 value of 17.9 ± 3.0 µg/mL; while no toxic effect on host cell was observed up to 200 µg/mL. This is the first report about the antileishmanial activity of Surfacen®.

【 授权许可】

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