Synthetic magainin analogues with improved antimicrobial activity

FEBS Letters

Chen, Hao-Chia²  Morell, John L.²  Huang, C.M.¹  Brown, Judith H.² 

[1] Clinical Pathology Department, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892 USA;Endocrinology and Reproduction Research Branch, National Institute of Child Health and Human Development Bethesda, MD 20892 USA

关键词: Peptide design;    Amphiphilic helix;    Antibiotic activity;    Structure-function relationship;   

DOI  :  10.1016/0014-5793(88)80077-2

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Based on modifications to enhance the α-helical structure of the broad spectrum antibiotic magainin 2, a series of analogues have been synthesized which display an increase up to two orders of magnitude in antimicrobial activity and, in the most favorable case, no appreciable increase in hemolytic activity over magainin 1 at the concentrations tested.

【 授权许可】

Unknown