Serological markers and risk factors for hepatitis B and C viruses in patients infected with human immunodeficiency virus

Revista do Instituto de Medicina Tropical de São Paulo

Alvaro Hoyos-orrego²  Mónica Massaro-ceballos²  Marta Ospina-ospina¹  Carolina Gómez-builes²  Nora Vanegas-arroyave²  Juan Tobón-pereira¹  Javier Jaramillo-hurtado¹  María Teresa Rugeles-lópez² 

[1] ,Universidad de Antioquia Biogénesis Grupo de InmunovirologíaMedellín,Colombia

关键词: Hepatitis B virus;    Hepatitis C virus;    Human immunodeficiency virus;    Risk factors;    Hepatitis C diagnosis;    Serological markers;   

DOI  :  10.1590/S0036-46652006000600004

来源: SciELO

【 摘 要 】

Both hepatitis B and hepatitis C viruses (HBV and HCV) infection are common in HIV-infected individuals as a result of shared risk factors for acquisition. A serological study for HBV and HCV was performed in 251 HIV-positive individuals from Medellín, Colombia. A qualitative RT-PCR for HCV was done in 90 patients with CD4+ T-cell count < 150 per mm³. Serological markers for HBV infection were present in 97 (38.6%) patients. Thirty six of them (37.1%) had isolated anti-HBc. A multivariate analysis indicated that the following risk factors were significantly associated with the presence of these markers: age (OR = 1.05, 95% CI: 1.01-1.08), pediculosis pubis (OR = 1.83, 95% CI: 1.01-3.33), men who have sex with men and women (OR = 3.23, 95% CI: 1.46-7.13) and men who have sex only with men (OR = 3.73, 95% CI: 1.58-8.78). The same analysis restricted to women showed syphilis as the only significant risk factor. Thus, HBV infection was considerably associated with high risk sexual behavior. HCV was present in only two (0.8%) of HIV patients. Both of them were positive by RT-PCR and anti-HCV. This low frequency of HIV/HCV coinfection was probably due to the uncommon intravenous drug abuse in this population. The frequent finding of isolated anti-HBc warrants molecular approaches to rule out the presence of cryptic HBV infection.

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