New Cytotoxic Steroid from Stachyurus himalaicus var. himalaicus

Molecules

Yun-Song Wang²  Jing-Hua Yang²  Shi-De Luo¹  Hong-Bin Zhang² 

[1] Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, P.R. China; E-mail:;Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming 650091, P.R. China; E-mails:

关键词: Steroids;    Stachyurus himalaicus var. himalaicus;    Stachyuraceae;    Cytotoxity;   

DOI  :  10.3390/12030536

来源: mdpi

【 摘 要 】

A phytochemical study of the ethanolic extract of Stachyurus himalaicus var. himalaicus was undertaken and as a result a new polyoxygenated steroid, named stachsterol ((20S)-20, 25-dihydroxy-4-cholesten-3-one, 1) and three known ecdysteroids, 20-hydroxyecdysone (2), 20-hydroxyecdysone-20, 22-monoacetonide (3) and polypodine B-20,22-monoacetonide (4), were isolated. Their structures were elucidated by spectroscopic methods, including UV, NMR, MS and HR-MS. The purified product 1 was found to have in vitro cytotoxic activity against human Hela cell lines with an IC₅₀ value of 2.5 μg/mL. This is the first time that phytoecdysteroids have been found in the genus Stachyurus.

【 授权许可】

Unknown   
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