Identification of sesquilignans in litchi (Litchi chinensis Sonn.) leaf and their anticancer activities

Journal of Functional Foods

卷:8

Jirui He¹  Mouming Zhao²  Yueming Jiang²  Wei Luo³  Lingrong Wen⁴  Sen Lin⁴  Bao Yang⁴  K. Nagendra Prasad⁴  Dan Wu⁴  Guoxiang Jiang⁵ 

[1] College of Light Industry and Food Sciences, South China University of Technology, Guangzhou 510640, China;

[2] University of Chinese Academy of Sciences, Beijing 100049, China;

[3] Key Laboratory of Plant Resource Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, China;

[4] School of Engineering, Monash University, Selangor 46150, Malaysia;

关键词: Litchi leaf;    Sesquilignans;    Lignan glycoside;    Antioxidant activity;    Cytotoxity;   

DOI  :  

来源: DOAJ

【 摘 要 】

Litchi (Litchi chinensis Sonn.) is a well-known traditional medicine since ancient times. The crude extract of litchi leaf exhibited good bioactivity against cancer cells. In this work, three sesquilignans, ehletianol C (1), sesquipinsapol B (2) and sesquimarocanol B (3), and one lignan glycoside schizandriside (4) were isolated from the ethyl acetate-soluble extract of litchi leaf by column chromatography. Their structures were further elucidated by ESI-MS and NMR spectral studies. Ehletianol C, sesquipinsapol B and sesquimarocanol B were detected from this species for the first time. Sesquipinsapol B (EC50 values less than 2.0 μg/mL) and sesquimarocanol B (EC50 values less than 2.4 μg/mL) showed very high cytotoxicities against nasopharynx carcinoma cells CNE1 and CNE2 cells, respectively. Thus, they could be utilized as good drug candidates against nasopharynx cancer. Moreover, three sesquilignans showed effective in vitro cytotoxicities against human cancer cells HepG2 and Hela. Four lignans showed better antioxidant activities than butylated hydroxytoluene (BHT).

【 授权许可】

Unknown