Oxidized low density lipoproteins elicit DNA fragmentation of cultured lymphoblastoid cells

FEBS Letters

Nègre-Salvayre, Anne¹  Salvayre, Robert¹  Escargueil, Isabelle¹  Pieraggi, Marie-Thérèse¹ 

[1] Department of Biochemistry, Metabolic Disease Laboratory, Faculty of Medicine in Rangueil, University Paul Sabatier, Toulouse, France

关键词: DNA fragmentation;    Apoptosis: Oxidized LDL;    Lymphoblastoid cell;    Calcium;    Cytotoxity;    EBV;    Epstein-Barr virus;    LDL;    low density lipoproteins;   

DOI  :  10.1016/0014-5793(92)80885-K

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Lymphoblastoid cell lines continuously pulsed with mildly oxidized low density lipoproteins, exhibited a significant increase of DNA fragmentation induced by oxidized LDL internalized by cells. DNA fragmentation was associated with an increasing number of morphologically characteristic apoptotic cells simultaneously with the increase of cytotoxicity indexes, and the activation of the poly(ADP-ribose) polymerase, a nuclear enzyme stimulated by DNA strand breaks. The potential involvement of these biochemical and morphological changes in antherogenesis is discussed.

【 授权许可】

Unknown