Antioxidant Activity of Diphenylpropionamide Derivatives: Synthesis, Biological Evaluation and Computational Analysis

Molecules

Paolo Urbani²  Anna Ramunno²  Rosanna Filosa²  Aldo Pinto²  Ada Popolo²  Erminia Bianchino²  Stefano Piotto²  Carmela Saturnino²  Rocco De Prisco¹  Barbara Nicolaus¹ 

[1] Institute of Biomolecular Chemistry-CNR, Via Campi Flegrei 34, 80078 Pozzuoli, (NA) Italy; E-mails:;Department of Pharmaceutical Sciences, University of Salerno,Via Ponte don Melillo, 84084 Fisciano, (SA) Italy; E-mails:

关键词: Diphenylpropionamide derivatives;    antioxidant activity;    brine shrimp test;    antiproliferative activity;    QSAR analysis;   

DOI  :  10.3390/molecules13040749

来源: mdpi

【 摘 要 】

We report the synthesis, antioxidant and antiproliferative activity and a QSAR analysis of synthetic diphenylpropionamide derivatives. Synthesis of these compounds was achieved by direct condensation of 2,2- and 3,3-diphenylpropionic acid and appropriate amines using 1-propylphoshonic acid cyclic anhydride (PPAA) as catalyst. Compound structures were elucidated by NMR analysis and their melting points were measured. The in vitro antioxidant activity of these compounds was tested by evaluating the amount of scavenged ABTS radical and estimating ROS and NO production in LPS stimulated J774.A1 macrophages. All compounds were tested for their effect on viability of cells and results demonstrated that they are not toxic towards the cell lines used. The cytotoxic activity of all compounds was evaluated by a Brine Shrimp Test.

【 授权许可】

Unknown   
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