Molecules | |
Acetamide Derivatives with Antioxidant Activity and Potential Anti-Inflammatory Activity | |
Giuseppina Autore1  Anna Caruso1  Stefania Marzocco1  Barbara Nicolaus1  Chiara Palladino1  Aldo Pinto1  Ada Popolo1  Maria S. Sinicropi1  Giuseppina Tommonaro1  | |
[1] 1Department of Pharmaceutical Sciences, University of Salerno, Fisciano (SA), Italy 2Institute of Biomolecular Chemistry, CNR, Pozzuoli (NA), Italy 3Department of Pharmaceutical Sciences, University of Cosenza, Arcavacate di Rende (CS), Italy | |
关键词: amides; antioxidant; antiproliferative activity; brine shrimp test; | |
DOI : 10.3390/molecules15032028 | |
来源: mdpi | |
【 摘 要 】
This study reports the synthesis and antioxidant activity of some new acetamide derivatives. The compounds’ structures were elucidated by NMR analysis and their melting points were measured. The in vitro antioxidant activity of these compounds was tested by evaluating the amount of scavenged ABTS radical and estimating ROS and NO production in tBOH- or LPS-stimulated J774.A1 macrophages. All compounds were tested for their effect on cell viability by an MTT assay and by a Brine Shrimp Test.
【 授权许可】
CC BY
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
【 预 览 】
Files | Size | Format | View |
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RO202003190054373ZK.pdf | 235KB | download |