Acetamide Derivatives with Antioxidant Activity and Potential Anti-Inflammatory Activity

Molecules

Giuseppina Autore¹  Anna Caruso¹  Stefania Marzocco¹  Barbara Nicolaus¹  Chiara Palladino¹  Aldo Pinto¹  Ada Popolo¹  Maria S. Sinicropi¹  Giuseppina Tommonaro¹ 

[1] ¹Department of Pharmaceutical Sciences, University of Salerno, Fisciano (SA), Italy ²Institute of Biomolecular Chemistry, CNR, Pozzuoli (NA), Italy ³Department of Pharmaceutical Sciences, University of Cosenza, Arcavacate di Rende (CS), Italy

关键词: amides;    antioxidant;    antiproliferative activity;    brine shrimp test;   

DOI  :  10.3390/molecules15032028

来源: mdpi

【 摘 要 】

This study reports the synthesis and antioxidant activity of some new acetamide derivatives. The compounds’ structures were elucidated by NMR analysis and their melting points were measured. The in vitro antioxidant activity of these compounds was tested by evaluating the amount of scavenged ABTS radical and estimating ROS and NO production in tBOH- or LPS-stimulated J774.A1 macrophages. All compounds were tested for their effect on cell viability by an MTT assay and by a Brine Shrimp Test.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.