Synthesis, Spectral and Solid State Characterization of a New Bioactive Hydrazine Bridged Cyclic Diphosphonium Compound

Molecules

Milica Milenković¹  Beata Warżajtis¹  Urszula Rychlewska¹  Dušanka Radanović¹  Katarina Anđelković¹  Tatjana Božić¹  Miroslava Vujčić¹ 

[1] ¹Faculty of Chemistry, University of Belgrade, Studentski trg 12-16, 11000 Belgrade, Serbia ²Faculty of Chemistry, A. Mickiewicz University, Grunwaldzka 6, 60-780 Poznań, Poland ³Institute of Chemistry, Technology and Metallurgy, University of Belgrade, Njegoševa 12, P.O. Box 815, 11000 Belgrade, Serbia

关键词: hydrazine bridged diphosphonium compound;    DNA cleavage;    brine shrimp test;    X-ray;   

DOI  :  10.3390/molecules17032567

来源: mdpi

【 摘 要 】

The facile preparation of a racemic hydrazine bridged diphosphonium compound possessing a ring system analogous to bicyclo[3.3.2]decane is reported. Although the reaction yield is low, the structure of the compound, which possesses an eight-membered ring, two phosphonium cationic centers, a biimino bridge, molecular chirality and two fused aromatic rings locked into roughly perpendicular planes is unusual. The compound displays substantial biological activity in the brine shrimp test and cleaves plasmid DNA.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.