Sinularones A–I, New Cyclopentenone and Butenolide Derivatives from a Marine Soft Coral Sinularia sp. and Their Antifouling Activity

Marine Drugs

Haiyan Shi²  Shanjiang Yu⁴  Dong Liu²  Leen van Ofwegen¹  Peter Proksch³ 

[1] National Museum of Natural History Naturalis, 2300 RA, Leiden 9515, The Netherlands;State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, China;Institute of Pharmaceutical Biology and Biotechnology, Heinrich-Heine University, Duesseldorf 40225, Germany;China National Center for Biotechnology Development, Beijing 100036, China;

关键词: soft coral;    Sinularia sp.;    sinularones A–I;    structural elucidation;    antifouling activity;   

DOI  :  10.3390/md10061331

来源: mdpi

【 摘 要 】

Nine new compounds, namely sinularones A–I (1–9), characterized as cyclopentenone and butenolide-type analogues, were isolated from a soft coral Sinularia sp., together with a known butenolide (10). Their structures were elucidated by means of spectroscopic (IR, MS, 1D and 2D NMR, CD) analysis. The absolute configurations were determined on the basis of CD and specific rotation data in association with the computed electronic circular dichroism (ECD) by time dependent density functional theory (TD DFT) at 6-31+G(d,p)//DFT B3LYP/6-31+G(d,p) level. Compounds 1–2 and 7–10 showed potent antifouling activities against the barnacle Balanus amphitrite.

【 授权许可】

CC BY   
© 2012 by the authors; licensee MDPI, Basel, Switzerland.