New Sinularianin Sesquiterpenes from Soft Coral Sinularia sp.

Marine Drugs

Bin Yang¹  Shengrong Liao¹  Xiuping Lin¹  Junfeng Wang¹  Juan Liu¹  Xuefeng Zhou¹  Xianwen Yang¹ 

[1] CAS Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica/Research Center for Marine Microbes, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China;

关键词: soft coral;    Sinularia sp.;    sesquiterpenes;    sinularianins;    NF-κB;   

DOI  :  10.3390/md11124741

来源: mdpi

【 摘 要 】

Four new sesquiterpenes, sinularianins C–F (3–6), together with known sinularianins A (1) and B (2) were identified from a South China Sea soft coral Sinularia sp. Compounds 1–6 were evaluated for inhibition of NF-κB activation using the cell-based HEK293 NF-κB luciferase reporter gene assay. Compounds 1 and 4 were exhibited a potent effect with inhibitory rates of 41.3% and 43.0% at the concentration of 10 µg/mL, respectively.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.