Sinulolides A–H, New Cyclopentenone and Butenolide Derivatives from Soft Coral Sinularia sp.

Marine Drugs

Bin Yang⁴  Xiaoyi Wei¹  Jingxia Huang²  Xiuping Lin⁴  Juan Liu⁴  Shengrong Liao⁴  Junfeng Wang⁴  Xuefeng Zhou⁴  Lishu Wang³  Yonghong Liu⁴ 

[1] Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, China; E-Mail:;Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou 510060, China; E-Mail:;Jilin Provincial Academy of Chinese Medicine Sciences, Changchun 130021, China; E-Mail:;Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, Research Center for Marine Microbes, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China; E-Mails:

关键词: soft coral;    Sinularia sp.;    sinulolide;    NF-κB;   

DOI  :  10.3390/md12105316

来源: mdpi

【 摘 要 】

Eight new compounds, sinulolides A–H (1–8), along with two known compounds, α-methoxy-2,3-dimethyl-butenolide (9) and sinularone D (10), were isolated from the soft coral Sinularia sp. The structures of these compounds were elucidated on the basis of extensive spectroscopic analysis. The absolute configurations were determined on the basis of electronic circular dichroism (ECD) data analysis. Compounds 5 and 10 exhibited moderate effects for the inhibition of NF-κB activation.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.