Polyoxygenated Sterols from the South China Sea Soft Coral Sinularia sp.

Marine Drugs

Rui Li¹  Chang-Lun Shao¹  Xin Qi¹  Xiu-Bao Li²  Jing Li¹  Ling-Ling Sun¹ 

[1] Key Laboratory of Marine Drugs, Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China;South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510000, China;

关键词: soft coral;    Sinularia sp.;    polyoxygenated sterols;    cytotoxicity;   

DOI  :  10.3390/md10071422

来源: mdpi

【 摘 要 】

Chemical investigation of the ethanol extract of soft coral Sinularia sp. collected from the South China Sea led to the isolation of three new polyoxygenated sterols, (3S,23R,24S)-ergost-5-ene-3β,23α,25-triol (1), (24S)-ergostane-6-acetate-3β,5α,6β,25-tetraol (2), (24S)-ergostane-6-acetate-3β,6β,12β,25-tetraol (3) together with three known ones (4–6). The structures, including relative configurations of the new compounds (1–3), were elucidated by detailed analysis of spectroscopic data (IR, UV, NMR, MS) and by comparison with related reported compounds. The absolute configuration of 1 was further determined by modified Mosher’s method. Compound 5 exhibited moderate cytotoxicity against K562 cell line with an IC₅₀ value of 3.18 μM, but also displayed strong lethality toward the brine shrimp Artemia salina with a LC₅₀ value of 0.96 μM.

【 授权许可】

CC BY   
© 2012 by the authors; licensee MDPI, Basel, Switzerland.