Long Chain N-acyl Homoserine Lactone Production by Enterobacter sp. Isolated from Human Tongue Surfaces

Sensors

Wai-Fong Yin²  Kathiravan Purmal¹  Shenyang Chin²  Xin-Yue Chan² 

[1] Department of General Dental Practice and Oral and Maxillofacial Imaging, Faculty of Dentistry, Universiti Sains Malaysia, 50603 Kuala Lumpur, Malaysia; E-Mail:;Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia; E-Mails:

关键词: N-acylhomoserine lactone;    N-dodecanoyl-L-homoserine lactone (C12-HSL);    oral cavity;    posterior dorsal surface;    quorum sensing;    tongue;   

DOI  :  10.3390/s121114307

来源: mdpi

【 摘 要 】

We report the isolation of N-acyl homoserine lactone-producing Enterobacter sp. isolate T1-1 from the posterior dorsal surfaces of the tongue of a healthy individual. Spent supernatants extract from Enterobacter sp. isolate T1-1 activated the biosensor Agrobacterium tumefaciens NTL4(pZLR4), suggesting production of long chain AHLs by these isolates. High resolution mass spectrometry analysis of these extracts confirmed that Enterobacter sp. isolate T1-1 produced a long chain N-acyl homoserine lactone, namely N-dodecanoyl-homoserine lactone (C12-HSL). To the best of our knowledge, this is the first isolation of Enterobacter sp., strain T1-1 from the posterior dorsal surface of the human tongue and N-acyl homoserine lactones production by this bacterium.

【 授权许可】

CC BY   
© 2012 by the authors; licensee MDPI, Basel, Switzerland.