Stem Cell Transplantation for Neuroprotection in Stroke

Brain Sciences

Kazutaka Shinozuka¹  Travis Dailey¹  Naoki Tajiri¹  Hiroto Ishikawa¹  Yuji Kaneko¹ 

[1] Center of Excellence for Aging & Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, 12901 Bruce B. Downs Blvd., Tampa, FL 33612, USA;

关键词: stem cells;    stroke;    cerebral ischemia;    transplantation;   

DOI  :  10.3390/brainsci3010239

来源: mdpi

【 摘 要 】

Stem cell-based therapies for stroke have expanded substantially over the last decade. The diversity of embryonic and adult tissue sources provides researchers with the ability to harvest an ample supply of stem cells. However, the optimal conditions of stem cell use are still being determined. Along this line of the need for optimization studies, we discuss studies that demonstrate effective dose, timing, and route of stem cells. We recognize that stem cell derivations also provide uniquely individual difficulties and limitations in their therapeutic applications. This review will outline the current knowledge, including benefits and challenges, of the many current sources of stem cells for stroke therapy.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.